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dc.contributor.authorBassetti, Matteo-
dc.contributor.authorRighi, Elda-
dc.date.accessioned2015-11-30T03:06:43Z-
dc.date.available2015-11-30T03:06:43Z-
dc.date.issued2013-
dc.identifier.urihttp://220.231.117.85:8000/handle/DHKTYTHD_123/324-
dc.description.abstractDespite big advances in antimicrobial therapies and infection strategies, the emergence of antibiotic resistance represents an emergency situation, especially in immunocompromised hosts. Specifically, infections due to multidrug resistant, gram-negative pathogens are responsible for high mortality rates and may leave few effective antimicrobial options. Furthermore, although new compounds are available for severe methicillin-resistant staphylococcal infections, there is a paucity of novel classes of antimicrobials to target resistant gram-negatives. A careful assessment of the clinical conditions and underlying comorbidities, along with knowledge about the previous history of colonization or infections due to multidrug-resistant bacteria, represent key points in approaching the hematological patient with signs of infection. A de-escalation therapy with initial use of wide-spectrum antimicrobials followed by a reassessment after 72 hours of treatment may represent a good option in severe infections if a resistant pathogen is suspected. Prompt empiric or targeted therapy using combination regimens (ie, antipseudomonal beta-lactam plus an aminoglycoside or a quinolone) with the addition of colistin, along with increased dosage and therapeutic drug monitoring, represent options for these life-threatening infections. Continuous epidemiological surveillance of local bacteremias is necessary, along with stringent enforcement of antibiotic stewardship programs in cancer patients.vi
dc.language.isoenvi
dc.publisherAmerican Society of Hematologyvi
dc.titleMultidrug-resistant bacteria: what is the threat?vi
dc.typeArticlevi
Appears in CollectionsHuyết học = Hematology

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