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http://dspace.hmtu.edu.vn/handle/DHKTYTHD_123/376
Title: | T-cell adoptive immunotherapy for acute lymphoblastic leukemia |
Authors: | Fry, Terry J. Mackall, Crystal L. |
Issue Date: | 2013 |
Publisher: | American Society of Hematology |
Abstract: | Substantial progress has been made in the treatment of precursor B-cell acute lymphoblastic leukemia (B-ALL), but recurrent disease remains a leading cause of death in children due to cancer and outcomes for adults with B-ALL remain poor. Recently, complete clinical responses have been observed in small numbers of patients with B-ALL treated with adoptive immunotherapy using T cells genetically engineered to express chimeric antigen receptors (CARs) targeting CD19, a cell surface molecule present in essentially all cases of B-ALL. Preclinical data suggest that CARs targeting CD22, another antigen present in the majority of B-ALL cases, are similarly potent. Several clinical studies already under way will soon more clearly define the rate of response to this novel therapy in B-ALL. Further work is needed to identify optimal platforms for CAR-based adoptive immunotherapy for leukemia, to establish guidelines for managing toxicity, and to determine whether the remissions induced by this approach can be rendered durable. |
URI: | http://220.231.117.85:8000/handle/DHKTYTHD_123/376 |
Appears in Collections | Huyết học = Hematology |
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File | Description | Size | Format | |
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Hematology-2013-Fry-348-53.pdf Restricted Access | 365.76 kB | Adobe PDF | Request Item |
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