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http://dspace.hmtu.edu.vn/handle/DHKTYTHD_123/383
Nhan đề : | Immunotherapeutic strategies including transplantation: eradication of disease |
Tác giả : | Gribben, John G. Riches, John C. |
Năm xuất bản : | 2013 |
Nhà xuất bản : | American Society of Hematology |
Tóm tắt : | Although there have been recent advances with targeted therapies in chronic lymphocytic leukemia (CLL), chemoimmunotherapy remains the treatment of choice; however, this approach is not curative. A key feature of CLL is that it induces a state of immunosuppression, causing increased susceptibility to infections and failure of an antitumor immune response, often worsened by the immunosuppressive effect of treatment. Because of its improved specificity, immunotherapy potentially offers a way out of this dilemma. Allogeneic stem cell transplantation remains the only curative option, but is hampered by the toxicity of GVHD. After many years of promise but little reward, many other immunotherapeutic approaches are now in transition to the clinical setting. Clinical trials including CLL vaccines, CXCR4 antagonists, and adoptive cellular immunotherapies such as chimeric antigen receptor–modified T cells, CD40 ligand gene therapy, and the immunomodulatory drug lenalidomide are ongoing. Results to date suggest that immunotherapeutic approaches for the treatment of CLL might finally be fulfilling their promise. |
URI: | http://220.231.117.85:8000/handle/DHKTYTHD_123/383 |
Bộ sưu tập | Huyết học = Hematology |
Danh sách tệp tin đính kèm:
Tên tệp tin | Mô tả tệp tin | Dung lượng | Định dạng | |
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Hematology-2013-Gribben-151-7.pdf Restricted Access | 435.56 kB | Adobe PDF | Gửi yêu cầu |
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